VP, Program Team Leader

Company: Dyne Therapeutics
Location: Waltham
Posted on: March 7, 2026

Job Description:

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Program Team Leader (PTL) is a passionate, globally minded drug developer who brings adaptable leadership, deep strategic product development expertise, and a relentless commitment to delivering transformative medicines to patients. As a highly visible leader, the PTL partners closely with an experienced Program Manager and a cross functional team to shape Program strategy, define goals and priorities, and chart an integrated plan that balances a future focused vision of global commercial access with the pragmatic decision-making needed to advance through complex development milestones. This role is based in Waltham, MA without the possibility of being a remote role. Primary Responsibilities Include: Program Leadership & Strategy Lead a high-performing, cross-functional Program Team by defining both the what (strategy, priorities, deliverables, and resources) and the how (a healthy, collaborative, and sustainable team environment). Establish, communicate, and continually evolve a robust Program strategy to deliver a life-changing medicine to patients in need. Ensure alignment of research, nonclinical, clinical, regulatory, CMC, and commercial strategies with the overarching Program strategy. Serve as the primary owner of Program recommendations across all stages of development, driving toward milestones, timelines, and value-creating decision points. Decision-Making & Communication Structure, facilitate, and drive timely, high-quality cross-functional decision-making with both the Program Team and senior leadership, ensuring all critical perspectives are appropriately considered. Prepare and deliver high-impact materials for the Board of Directors, Scientific Advisory Board, and other key governance bodies. Maintain clear, open, and proactive communication with senior leadership regarding Program strategy, progress, risks, dependencies, and resource needs. Scientific & External Engagement Stay abreast of emerging scientific and development trends in muscle diseases and oligonucleotide drug discovery and development. Build a visible, credible presence within the KOL and patient advocacy communities for the relevant disease areas. Participate in business development activities as needed, including opportunity evaluations and due diligence. Organizational Leadership Model and reinforce company values, especially during periods of rapid growth and change. Serve as a primary advocate for the Program within the broader portfolio and corporate strategic context. Collaborate with Finance and functional leaders to responsibly manage the Program budget. Foster a culture of scientific excellence, innovation, open communication, and continuous improvement. Actively coach and support team members to help them perform at their best, and identify or mitigate skill or capacity gaps within the team. Consider needs of the Program in context of Dyne corporate strategy and priorities, as primary advocate for the Program among Dyne senior leadership Education and Skills Requirements Experience in Phase 1-3 drug development is required; product launch/early commercialization experience a strong plus Proven and respected leader with: Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent 20 years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving Programs through IND, early clinical, pivotal stages and approval And/or at least 12 years in pharmaceutical industry in significant development and/or commercial leadership or general management positions including working with development teams in cross-functional setting, with exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and strong knowledge of neuromuscular diseases Experience in rare genetic diseases preferred Other key traits: Entrepreneurial team leader, able to shape and communicate the vision for an important therapeutic Program and guiding the development of the product strategy and its execution Insightful people leader supporting and coaching high-caliber functional experts to achieve their absolute best Collaborative corporate leader partnering with other senior leaders to shape and fulfil Dyne’s overall mission to develop and commercialize transformational therapeutics for people living with serious diseases Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product Adept at leading through ambiguity and provide steadiness and consistency among shifting priorities Comfortable with fast-paced and nimble organizational environment Demonstrated experience in building highly effective and motivated cross-functional teams and in guiding teams and organizations in making complex and high-stakes data-driven decisions Proven acumen for cross-functional leadership and influencing without direct authority, both among cross-functional team members and senior functional leaders Demonstrated scientific knowledge and curiosity necessary for thought partnership across all functions Proven ability to establish and maintain credible and trust-based relationships with external stakeholders (e.g., KOLs, patient advocacy groups, regulators or investors) Outstanding sense of urgency and ability to pace the team’s work to achieve milestone achievement in highly competitive landscape Excellent communication skills (verbal, written, presentation) and ability to clearly communicate complex ideas stakeholders and teams at all levels Natural focus on team dynamics and proven ability to coach and support team members to perform at their best Effective people-oriented collaboration skills in an environment with cross internal functional teams, and third-party collaborators/vendors Team player and mentor, who listens effectively and invites response and discussion Collaborator who communicates in an open, clear, complete, timely and consistent manner MA Pay Range $288,000 - $350,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Keywords: Dyne Therapeutics, Middletown , VP, Program Team Leader, Manufacturing , Waltham, Connecticut