Executive Director/Vice President, Oligonucleotide Chemistry

Company: ECL Kontor
Location: Somerville
Posted on: May 3, 2025

Job Description:

Somerville, Massachusetts, United StatesMinimum Qualifications:

• PhD in synthetic organic chemistry or process chemistry, and 13+ years of relevant experience.
• Deep understanding of modern methods in synthetic chemistry with an emphasis on nucleosides, nucleotides and oligonucleotide synthesis, and purification and analytical characterization as applied to nucleic acid therapeutics.
• Oligonucleotide manufacturing including CRO and CMO capabilities, familiarity with GMP requirements.
• Contributions to IND, BLA and regulatory filings.
• Strong organizational leadership skills with a proven track record in setting vision/strategy and managing team execution to achieve key company milestones.
• Lead efforts to identify emerging trends in the oligonucleotide therapeutics field and maintain awareness of the competitive landscape.
• Prior experience with long oligos via chemical synthesis or ligation is desirable.Responsibilities:
  • Developing oligonucleotide chemistry vision, strategy, and tactics including overseeing timelines, resourcing and budget planning.
  • Building a world-class oligonucleotide CMC team/platform, including new lab buildout, to support the Tessera pipeline.
  • Lead external manufacturing of oligo with CMOs to support GLP tox studies and IND submissions.
  • Independently leading both internal team and external CRO partners; identifying, developing, and implementing both existing oligo chemistries and developing next-generation chemistry solutions.
  • Working effectively with a cross-functional and highly collaborative biology, technology, and chemistry team to contribute to the delivery of key organizational goals/milestones.About You:You are an experienced leader with a proven track record of scientific excellence in the oligonucleotide chemistry space. You have demonstrated success in team leadership/organization, platform building and development of oligos including a strong publication and patent record. You have hands-on experience driving technologies towards the clinics including knowledge related to IND filing.Tessera leaders are empathetic and transparent coaches with a strong sense of integrity. They are committed to the growth and development of their teams, the organization and themselves.Leadership Structure:This position reports to: Sandeep Nema - Senior Vice President, Technical Development.About Tessera Therapeutics:Tessera Therapeutics is pioneering Gene Writing-a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.Equal Opportunity Employment:Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with Tessera regarding a reasonable accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied, please contact the recruiter or Accommodations@tesseratx.com.Recruitment & Staffing Agencies:Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics' internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.Apply for this job* indicates a required field
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Keywords: ECL Kontor, Middletown , Executive Director/Vice President, Oligonucleotide Chemistry, Executive , Somerville, Connecticut